Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A
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چکیده
منابع مشابه
Plasma interleukin-27 levels in patients with coronary artery disease
Interleukin (IL)-27, one of cytokines in the IL-12 family, is considered to have both pro- and anti-inflammatory properties. However, blood IL-27 levels in coronary artery disease (CAD) have not been fully elucidated yet. This cross-sectional study was done to elucidate the association between blood IL-27 levels and CAD.We investigated plasma IL-27 and high-sensitivity C-reactive protein (hsCRP...
متن کاملInterleukin-17A and interleukin-23 in morphea
INTRODUCTION Morphea is a disease included in the group of scleroderma type autoimmune diseases. Interleukin (IL)-17A may play a role at every stage of its pathogenesis. The study aimed at evaluation of IL-17A and IL-23 (as the main cytokine which is supposed to stimulate and maintain synthesis of IL-17) in pathogenesis of morphea. MATERIAL AND METHODS The studies were performed on 41 blood s...
متن کاملInterleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis
Bakground: Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system (CNS). It was previously believed that Th1 cells were pathogenic T cells in experimental autoimmune encephalomyelitis (EAE). However, the functional role of Th1 cells in EAE has been reconsidered upon the discovery of IL-17- producing T cells which are consider as dominant effect...
متن کاملPlasma Interleukin-27 (IL-27) Levels Are Not Modulated in Patients with Chronic HIV-1 Infection
OBJECTIVE IL-27 is an immunomodulatory cytokine with potent anti-HIV properties in PBMCs, CD4+ T cells, macrophages and immature dendritic cells. Previous smaller studies have suggested that HIV-1 infection may alter IL-27 and influence HIV-1 pathogenesis. The aim of this study was to examine the relationship between plasma IL-27 levels in a well-characterised cohort of HIV-1 infected patients....
متن کاملserum levels of interleukin-27 and interleukin-33 in patients with dermatomyositis and polymyositis compared to healthy control subjects
background in some autoimmune diseases such as rheumatoid arthritis (ra), interleukin-27 (il-27) and il-33 levels are increased. these observations suggest that il-27 and il-33 may have a role in the pathogenesis of polymyositis/dermatomyositis (pm/dm). conclusions these data indicate that il-27 might be selectively involved in the pathogenesis of dm and pm. however, il-33 does not appear to be...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2014
ISSN: 0009-9104
DOI: 10.1111/cei.12408